Management 4900 Essay Example | Topics and Well Written Essays - 2500 words

Management 4900 - Essay ExampleIt should state the result, its significance and any other conclusion(s), which may be relevant.Introduction A novel mouse mutant and the corresponding protein, mKIAA058 (in the following KIAA), was identified and further analysed. In holy order to understand the functions of this gene/protein, a mouse strain containing a non-functional allele (mKiAA058- Null-allele) was successfully established. jump data indicated an autosomal recessive inheritance as heterozygous (KIAA+/-) as well as homozygous knockout (KIAA-/-) animals were identified. The deficiency of this protein (Knockout KIAA) affects multiple tissues, including skeletal defects (delayed/reduced development of bone and cartilage harvest-festival retardation) as well as a progressive form of vascular degeneration. Later, a corresponding sickness in humans was found in a small number of very young patients. The prospects of the patients be not clear at the time and the analysis of the mouse model may provide virtually hints for the severity of the disease. The analyses of the molecular mechanisms underlying the disease be still ongoing and some problems and experiments linked to these studies are given in the following. Statistical tests may be used to answer some of the questions.In order to define potential effects of the presence/absence of the KIAA protein on the inheritance patterns, a number of breedings were performed. The genotypes of the parents were cognize and the genotypes of the litters (age 14-16 days) were analysed by allele-specific PCR reactions.In three parallel experiments (1.1, 1.2, 1.3), crossings of 5 wildtype males (KIAA+/+) with 10 heterozygous females (KIAA+/-) were started and all litters (given as impart number of mice) were genotyped and the numbers of all possible genotypes are given in the following Table 1. altogether tested mice appear normal and show no altered phenotype at the tested age (day 14-16).In three parallel